2'-Deoxy-2'-fluorouridine

Names

[ Name ]:
2'-Deoxy-2'-fluorouridine

[Synonym ]:
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
2'-Deoxy-2'-fluorouridine
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione
Uridine, 2'-deoxy-2'-fluoro-
2'-Fluoro-2'-deoxyuridine
1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)uracil

Biological Activity

[Description]:

1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₉H₁₁FN₂O₅

[ Molecular Weight ]:
246.19

[ Exact Mass ]:
246.065201

[ PSA ]:
104.55000

[ LogP ]:
-1.31

[ Index of Refraction ]:
1.608

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ9512000

CHEMICAL NAME :: Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-

CAS REGISTRY NUMBER :: 69123-94-0

LAST UPDATED :: 198708

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H15-F-N2-O5

MOLECULAR WEIGHT :: 274.28

WISWESSER LINE NOTATION :: T6NVMVJ E2 A- BT5OTJ CF DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - rat Bone marrow

DOSE/DURATION :: 3700 umol/L

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 26,333,1985

Safety Information

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%