Hydrangel 8-O-glucoside

Names

[ Name ]:
Hydrangel 8-O-glucoside

[Synonym ]:
1H-2-Benzopyran-1-one, 8-(β-D-glucopyranosyloxy)-3,4-dihydro-3-(4-hydroxyphenyl)-
3-(4-Hydroxyphenyl)-1-oxo-3,4-dihydro-1H-isochromen-8-yl β-D-glucopyranoside

Biological Activity

[Description]:

Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) can be isolated from Hydrangea macrophyllu. Hydrangenol 8-O-glucoside is an AChE inhibitor (IC50: 22.66 μM). Hydrangenol 8-O-glucoside inhibits passive cutaneous anaphylaxis (PCA) reaction[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Matsuda H, et al. Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats. Biol Pharm Bull. 1999 Aug;22(8):870-2.

[2]. Hwang J, et al. Discovery of Natural Inhibitors of Cholinesterases from Hydrangea: In Vitro and In Silico Approaches. Nutrients. 2021 Jan 17;13(1):254.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
763.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₂O₉

[ Molecular Weight ]:
418.39

[ Flash Point ]:
272.0±26.4 °C

[ Exact Mass ]:
418.126373

[ PSA ]:
145.91000

[ LogP ]:
-0.39

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.670

Safety Information

[ Hazard Codes ]:
Xi

Hydrangel 8-O-glucoside

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Precursor & DownStream

Precursor

DownStream

Related Compounds