Pamoic acid disodium

Names

[ Name ]:
Pamoic acid disodium

[Synonym ]:
Pamoic acid disodium salt
embonic acid disodium salt
MFCD00036183
pamoate disodique
disodium 4,4'-methylene-bis(3-hydroxy-2-naphthoate)
dipotassium pamoate(2-)
sodium embonate
Disodium 4,4'-methylenebis(3-hydroxy-2-naphthoate)
Pamoic acid,disodium salt
PAMOIC ACID,Na
Sodium pamoate
disodium 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate
Disodium pamoate
disodium 4-[(3-carboxylato-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate
2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, sodium salt (1:2)
Disodium methylenebis(2-hydroxy-3-naphthoate)
EINECS 229-653-1

Biological Activity

[Description]:

Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Research Areas >> Neurological Disease

Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

EC50: 79 nM (GPR35), 65 nM (ERK1/2)[1]

[References]

[1]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8.

Chemical & Physical Properties

[ Boiling Point ]:
642.7ºC at 760 mmHg

[ Melting Point ]:
300 °C

[ Molecular Formula ]:
C₂₃H₁₄Na₂O₆

[ Molecular Weight ]:
432.333

[ Flash Point ]:
356.5ºC

[ Exact Mass ]:
432.058563

[ PSA ]:
120.72000

[ LogP ]:
1.72200

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S24/25

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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