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Bouvardin,5-(N-methyl-L-tyrosine)- (9CI)

Names

[ CAS No. ]:
64725-24-2

[ Name ]:
Bouvardin,5-(N-methyl-L-tyrosine)- (9CI)

[Synonym ]:
Desoxybenzoin-semicarbazon
1,2-diphenyl-ethanone semicarbazone
Semicarbazon des Phenyl-benzyl-ketons
deoxybouvadin
Benzyl-phenyl-keton-semicarbazon
1,2-Diphenyl-1-semicarbazonoethan
deoxybenzoin semicarbazone

Biological Activity

[Description]:

RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC50 values of 50, 75, and 93 ng/mL, respectively. RA-V can be used for the research of cancer-related signaling pathways.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> Wnt
Signaling Pathways >> Stem Cell/Wnt >> Notch
Signaling Pathways >> Apoptosis >> c-Myc

[Target]

IC50: 50 ng/mL (Wnt); 75 ng/mL (Myc), 93 ng/mL (Notch)[1]


[In Vivo]

RA-V 对 Wnt、Myc 和 Notch 具有活性，IC50 值分别为 50、75 和 93 ng/mL[1]。

[References]

[1]. Premalatha Balachandran, et al. Crosstalk of Cancer Signaling Pathways by Cyclic Hexapeptides and Anthraquinones from Rubia cordifolia. Molecules. 2021 Jan 31;26(3):735.  

Chemical & Physical Properties

[ Density]:
1.189g/cm3

[ Boiling Point ]:
1083.3ºC at 760mmHg

[ Molecular Formula ]:
C40H48N6O9

[ Molecular Weight ]:
756.84400

[ Flash Point ]:
609ºC

[ Exact Mass ]:
756.34800

[ PSA ]:
186.92000

[ LogP ]:
2.34320

[ Index of Refraction ]:
1.544

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ED9610000
CAS REGISTRY NUMBER :
64725-24-2
LAST UPDATED :
198702
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C40-H48-N6-O9.5/4H2-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 32,3216,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
34 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 32,3216,1984

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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