Moclobemide N-Oxide

Names

[ Name ]:
Moclobemide N-Oxide

[Synonym ]:
Ro 12-5637
4-Chloro-N-[2-(4-oxido-4-morpholinyl)ethyl]benzamide
Benzamide, 4-chloro-N-[2-(4-oxido-4-morpholinyl)ethyl]-
4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide N-Oxide

Biological Activity

[Description]:

Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[Target]

MAO-A

[References]

[1]. Rakic Ignjatovic A, et al. Moclobemide monotherapy vs. combined therapy with valproic acid or carbamazepine in depressive patients: a pharmacokinetic interaction study. Br J Clin Pharmacol. 2009 Feb;67(2):199-208.

[2]. Geschke R, et al. Determination of the new monoamine oxidase inhibitor moclobemide and three of its metabolites in biological fluids by high-performance liquid chromatography. J Chromatogr. 1987 Sep 4;420(1):111-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₇ClN₂O₃

[ Molecular Weight ]:
284.74

[ Exact Mass ]:
284.092773

[ LogP ]:
-0.10

Related Compounds

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