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Val-Cit-PAB-MMAE

Names

[ CAS No. ]:
644981-35-1

[ Name ]:
Val-Cit-PAB-MMAE

[Synonym ]:
L-Ornithinamide, L-valyl-N-(aminocarbonyl)-N-[4-[(5S,8S,11S,12R)-12-[2-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-oxoethy l]-4,10-dimethyl-5,8-bis(1-methylethyl)-11-[(1S)-1-methylpropyl]-3,6,9-trioxo-2,13-dioxa-4,7,10-triazatetradec-1-yl]phenyl]-
L-Valyl-N-{4-[(5S,8S,11S,12R)-11-[(2S)-2-butanyl]-12-(2-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenyl-2-propanyl]amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-2-oxoethyl)-5,8-diisopropyl-4, ;10-dimethyl-3,6,9-trioxo-2,13-dioxa-4,7,10-triazatetradec-1-yl]phenyl}-N-carbamoyl-L-ornithinamide

Biological Activity

[Description]:

Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the peptide Val-Cit-PAB.

[Related Catalog]:

Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC
Research Areas >> Cancer

[Related Small Molecules]

VcMMAE | Mertansine | dm1-smcc | McMMAF | Mc-MMAE | Acetylene-linker-Val-Cit-PABC-MMAE | Deruxtecan analog | SPDB-DM4 | Fmoc-Val-Cit-PAB-MMAE | Mc-MMAD | sulfo-SPDB-DM4

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1211.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C58H94N10O12

[ Molecular Weight ]:
1123.427

[ Flash Point ]:
686.7±34.3 °C

[ Exact Mass ]:
1122.705322

[ LogP ]:
4.80

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.552

[ Storage condition ]:
2-8℃

Related Compounds