Acetylene-linker-Val-Cit-PABC-MMAE

Names

[ CAS No. ]:
1411977-95-1

[ Name ]:
Acetylene-linker-Val-Cit-PABC-MMAE

[Synonym ]:
L-Ornithinamide, N-[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]acetyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[(5S,8S,11S,12R)-12-[2-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-meth oxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-oxoethyl]-4,10-dimethyl-5,8-bis(1-methylethyl)-11-[(1S)-1-methylpropyl]-3,6,9-trioxo-2,13-dioxa-4,7,10-triazatetradec-1-yl]phenyl]-
N-({2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy}acetyl)-L-valyl-N-{4-[(5S,8S,11S,12R)-11-[(2S)-2-butanyl]-12-(2-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenyl-2-propanyl]amino}-1-methoxy-2-methyl-3-oxopropy ;l]-1-pyrrolidinyl}-2-oxoethyl)-5,8-diisopropyl-4,10-dimethyl-3,6,9-trioxo-2,13-dioxa-4,7,10-triazatetradec-1-yl]phenyl}-N5-carbamoyl-L-ornithinamide
LCB14-0602

Biological Activity

[Description]:

Acetylene-linker-Val-Cit-PABC-MMAE consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE), Acetylene-linker-Val-Cit-PABC-MMAE is an antibody drug conjugate.

[Related Catalog]:

Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC

Research Areas >> Cancer

[References]

[1]. PROTEIN-ACTIVE AGENT CONJUGATES AND METHOD FOR PREPARING THE SAME. WIPO Patent Application WO/2012/153193.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1312.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆₇H₁₀₆N₁₀O₁₆

[ Molecular Weight ]:
1307.616

[ Flash Point ]:
747.3±34.3 °C

[ Exact Mass ]:
1306.778809

[ LogP ]:
5.33

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.544

[ Storage condition ]:
2-8℃

Related Compounds

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