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Xanthoangelol

Names

[ CAS No. ]:
62949-76-2

[ Name ]:
Xanthoangelol

[Synonym ]:
Xanthoangelol
xanthoangerol
2',4,4'-trihydroxy-3'-geranylchalcone
3-geranyl-2,4,4'-trihydroxychalcone

Biological Activity

[Description]:

Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity[1][2]. Xanthoangelol and inhibits monoamine oxidases[3]. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells[4].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> Epigenetics >> AMPK
Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Li Y, et al. Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses. Obesity (Silver Spring). 2016 Nov;24(11):2351-2360.

[2]. Inamori Y, et al. Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI. Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1604-5.

[3]. Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul). 2013 May 30;21(3):234-40.

[4]. Keiichi TABATA, et al. Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells. Biol. Pharm. Bull. 28(8) 1404-1407 (2005).

Chemical & Physical Properties

[ Density]:
1.165g/cm3

[ Boiling Point ]:
605.8ºC at 760 mmHg

[ Molecular Formula ]:
C25H28O4

[ Molecular Weight ]:
392.48700

[ Flash Point ]:
334.2ºC

[ Exact Mass ]:
392.19900

[ PSA ]:
77.76000

[ LogP ]:
5.93470

[ Index of Refraction ]:
1.625

Synthetic Route

Click to get detail synthetic route

Related Compounds

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