4-Hydroxybenzamide

Names

[ CAS No. ]:
619-57-8

[ Name ]:
4-Hydroxybenzamide

[Synonym ]:
4-Hydroxybenzamide
Benzamide,4-hydroxy
EINECS 210-602-7
4-hydroxy-benzamide
4-Hydroxybenzolcarboxamid
MFCD00007997
4-hydroxyphenylformamide
4-Hydroxy-benzoesaeure-amid
Benzamide, 4-hydroxy-
para-hydroxybenzamide
P-HYDROXYBENZAMIDE
4-hydroxy-benzoic acid amide
4-Hydroxy-benzamid
4-Hydroxybenzamide (p-Hydroxybenzamide)
Benzamide,p-hydroxy

Biological Activity

[Description]:

4-Hydroxybenzamide, found in the herb of Berberis pruinosa, is a known natural product that has potential to slow down the progression of atherosclerosis[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Habsah Mohamad, et al. Potential Secondary Metabolites from Marine Sponge Aaptos aaptos for Atherosclerosis and Vibriosis Treatments. Natural Product Communications. 2017. 12(8):1227-1230.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
345.3±25.0 °C at 760 mmHg

[ Melting Point ]:
161-162 °C(lit.)

[ Molecular Formula ]:
C₇H₇NO₂

[ Molecular Weight ]:
137.136

[ Flash Point ]:
162.6±23.2 °C

[ Exact Mass ]:
137.047684

[ PSA ]:
63.32000

[ LogP ]:
0.25

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.612

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Influence of Secondary Interactions on the Structure, Sublimation Thermodynamics, and Solubility of Salicylate:4-Hydroxybenzamide Cocrystals. Combined Experimental and Theoretical Study.

J. Phys. Chem. B 119 , 10466-77, (2015)

Cocrystal screening of 4-hydroxybenzamide with a number of salicylates (salicylic acid, SA; 4-aminosalicylic acid, PASA; acetylsalicylic acid, ASA; and salicylsalicylic acid, SSA) was conducted to con...

Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety.

J. Med. Chem. 40(2) , 226-35, (1997)

Balanol is a potent protein kinase C (PKC) inhibitor that is structurally composed of a benzophenone diacid, a 4-hydroxybenzamide, and a perhydroazepine ring. A number of balanol analogs in which the ...

Energetics of the O-H bond and of intramolecular hydrogen bonding in HOC6H4C(O)Y (Y = H, CH3, CH2CH=CH2, C[triple bond]CH, CH2F, NH2, NHCH3, NO2, OH, OCH3, OCN, CN, F, Cl, SH, and SCH3) compounds.

J. Phys. Chem. A 112(40) , 10029-39, (2008)

The energetics of the phenolic O-H bond in a series of 2- and 4-HOC 6H 4C(O)Y (Y = H, CH3, CH 2CH=CH2, C[triple bond]CH, CH2F, NH2, NHCH 3, NO2, OH, OCH3, OCN, CN, F, Cl, SH, and SCH3) compounds and o...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.