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Tasimelteon

Names

[ CAS No. ]:
609799-22-6

[ Name ]:
Tasimelteon

[Synonym ]:
Hetlioz
Tasimelteon
MA 1
N-[[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl]propanamide
UNII-SHS4PU80D9
Propanamide, N-[[(1R,2R)-2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]-
N-{[(1R,2R)-2-(2,3-Dihydro-1-benzofuran-4-yl)cyclopropyl]methyl}propanamide
VEC-162

Biological Activity

[Description]:

Tasimelteon is a melatonin MT1 and MT2 receptor agonist.Target: melatonin receptorTasimelteon is a novel circadian regulator, is the first product for the treatment of Non-24-hour Sleep-Wake Disorder (Non-24) approved by either the FDA or the European Medicines Agency (EMA). Tasimelteon is a potent and specific melatonin (MT1 and MT2) receptor agonist with 2 - 4 times greater affinity for the MT2 receptor.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor
Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor
Research Areas >> Neurological Disease

[References]

[1]. Leger D, et al. Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies. Expert Opin Drug Saf. 2015;14(11):1673-85.

[2]. Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.


[Related Small Molecules]

Melatonine | Ramelteon | Ramelteon metabolite M-II

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
442.6±24.0 °C at 760 mmHg

[ Melting Point ]:
78°C(lit.)

[ Molecular Formula ]:
C15H19NO2

[ Molecular Weight ]:
245.317

[ Flash Point ]:
221.4±22.9 °C

[ Exact Mass ]:
245.141586

[ PSA ]:
38.33000

[ LogP ]:
1.75

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
2-8°C

Related Compounds