1-METHYLPIPERIDIN-4-YL 2,2-DIPHENYL-2-PROPOXYACETATE

Names

[ Name ]:
1-METHYLPIPERIDIN-4-YL 2,2-DIPHENYL-2-PROPOXYACETATE

[Synonym ]:
Propiverine

Biological Activity

[Description]:

Propiverine is a potent antimuscarinic agent. Propiverine inhibits cellular calcium influx, thereby diminishing muscle spasm. Propiverine has neurotropic and musculotropic effects on the urinary bladder smooth muscle. Propiverine can used for overactive bladder (OAB) research[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[References]

[1]. McKeage K. Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms. Clin Drug Investig. 2013 Jan;33(1):71-91.

[2]. Madersbacher H, Mürtz G. Efficacy, tolerability and safety profile of propiverine in the treatment of the overactive bladder (non-neurogenic and neurogenic). World J Urol. 2001 Nov;19(5):324-35.

Chemical & Physical Properties

[ Density]:
1.08 g/cm3

[ Boiling Point ]:
468.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₉NO₃

[ Molecular Weight ]:
367.48

[ Flash Point ]:
134.6ºC

[ Exact Mass ]:
367.21500

[ PSA ]:
38.77000

[ LogP ]:
3.93210

[ Index of Refraction ]:
1.57

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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