Guvacine hydrobromide

Names

[ Name ]:
Guvacine hydrobromide

[Synonym ]:
1,2,5,6-tetrahydro-pyridine-3-carboxylic acid , hydrobromide
1,2,5,6-Tetrahydro-pyridin-3-carbonsaeure, Hydrobromid

Biological Activity

[Description]:

Guvacine hydrobromide, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine hydrobromide inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

IC50: 39 μM (rat GAT-1), 58 μM (rat GAT-2), 378 μM (rat GAT-3), 14 μM (human GAT-1), 119 μM (huam GAT-3) and 1870 μM (human BGT-3)[1]

[References]

[1]. L A Borden, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₀BrNO₂

[ Molecular Weight ]:
208.05

[ Exact Mass ]:
206.98900

[ PSA ]:
49.33000

[ LogP ]:
1.27760

Precursor & DownStream

Precursor

DownStream

Related Compounds

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