NSC 146109 (hydrochloride)

Names

[ Name ]:
NSC 146109 (hydrochloride)

[Synonym ]:
10-Methyl-9-anthrylmethylisothioharnstoff Hydrochlorid

Biological Activity

[Description]:

NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and could be of value in treating breast cancer.NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> MDM-2/p53

[References]

[1]. Wang H, et al. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia. 2011 Jul;13(7):611-9.

Chemical & Physical Properties

[ Density]:
1.23g/cm3

[ Boiling Point ]:
493.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₇ClN₂S

[ Molecular Weight ]:
316.84800

[ Flash Point ]:
252.3ºC

[ Exact Mass ]:
316.08000

[ PSA ]:
61.18000

[ LogP ]:
5.98580

[ Index of Refraction ]:
1.665

Related Compounds

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