NSC 694621

Names

[ Name ]:
NSC 694621

Biological Activity

[Description]:

NSC 694621 is a potent PCAF inhibitor, with an IC50 of 5.71 µM (PCAF/H31-21). NSC 694621 exhibits good activity of inhibiting the proliferation of cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

[Target]

IC50: 5.71 µM (PCAF/H31-21)[1].

[In Vitro]

NSC 694621 (25 µM; 72 h) exhibits antiproliferative effect to SK-N-SH and HCT116 cells[1]. Cell Proliferation Assay[1] Cell Line: SK-N-SH, HCT116 cells Concentration: 25 µM Incubation Time: 72 h Result: Showed antiproliferative effect to SK-N-SH and HCT116 cells with GI50 of 19.2 µM and growth inhibition of 29%, respectively.

[References]

[1]. Furdas SD, et al. Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₀N₂O₂S

[ Molecular Weight ]:
258.30

Related Compounds

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