NSC 624206

Names

[ Name ]:
NSC 624206

[Synonym ]:
Decylamine, N-(2-((p-chlorobenzyl)dithio)ethyl)-, hydrochloride
MFCD01736096
1-Decanamine, N-[2-[[(4-chlorophenyl)methyl]dithio]ethyl]-, hydrochloride (1:1)
N-(2-((p-Chlorobenzyl)dithio)ethyl)decylamine hydrochloride
N-(2-((4-Chlorobenzyl)dithio)ethyl)-1-decanamine hydrochloride
N-{2-[(4-Chlorobenzyl)disulfanyl]ethyl}-1-decanamine hydrochloride (1:1)

Biological Activity

[Description]:

NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme

[Target]

IC50: ~9 μM (ubiquitin E1)[1]

[In Vitro]

NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line[1]. NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC50 of 13 μM[1]. NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells[1]. Western Blot Analysis[1] Cell Line: Kip16 cells Concentration: 10 nM-10 μM Incubation Time: 24 hours Result: Induced accumulation of p27.

[References]

[1]. Dana Ungermannova, et al. Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor. J Biomol Screen . 2012 Apr;17(4):421-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₃₃Cl₂NS₂

[ Molecular Weight ]:
410.508

[ Exact Mass ]:
409.143158

Related Compounds

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