tert-Butoxy bis(dimethylamino)methane

Names

[ Name ]:
tert-Butoxy bis(dimethylamino)methane

[Synonym ]:
Bredereck’s reagent
Methanediamine, 1-(1,1-dimethylethoxy)-N,N,N',N'-tetramethyl-
tert-Butoxy bis(dimethylamino)methane
EINECS 227-383-9
tert-butoxybis(dimethylamino)methane
Brederick’s reagent
MFCD00042858
N,N,N',N'-Tetramethyl-1-[(2-methyl-2-propanyl)oxy]methanediamine
1-tert-Butoxy-N,N,N',N'-tetramethylmethanediamine
EINECS 227-383-9

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
176.9±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₂₂N₂O

[ Molecular Weight ]:
174.284

[ Flash Point ]:
35.2±19.0 °C

[ Exact Mass ]:
174.173218

[ PSA ]:
15.71000

[ LogP ]:
2.14

[ Vapour Pressure ]:
1.1±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.446

[ Storage condition ]:
Freezer (-20°C)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

Chem. Biol. 18 , 67-76, (2011)

There is a growing recognition of the importance of protein kinases in the control of alternative splicing. To define the underlying regulatory mechanisms, highly selective inhibitors are needed. Here...

Macrocyclization by nickel-catalyzed, ester-promoted, epoxide-alkyne reductive coupling: total synthesis of (-)-gloeosporone.

Angew. Chem. Int. Ed. Engl. 48(29) , 5366-8, (2009)

Ringing the changes: The total synthesis of the title compound centers around a novel strategy that employs a nickel(0)-phosphine complex and triethyl borane in an efficient closure of a 14-membered r...

First total synthesis of the 2,7-naphthyridine alkaloids lophocladine a and B.

Arch. Pharm. (Weinheim) 339(12) , 677-9, (2006)

The one-pot reaction of 4-benzylpyridine-3-carbonitrile with Bredereck's reagent and subsequent treatment with either glacial acetic acid and sulfuric acid or ammonium acetate provided the new bioacti...