Archiv der Pharmazie (Weinheim) 2006-12-01

First total synthesis of the 2,7-naphthyridine alkaloids lophocladine a and B.

Matthias Lotter, Johannes Schilling, Eberhard Reimann, Franz Bracher

Index: Arch. Pharm. (Weinheim) 339(12) , 677-9, (2006)

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Abstract

The one-pot reaction of 4-benzylpyridine-3-carbonitrile with Bredereck's reagent and subsequent treatment with either glacial acetic acid and sulfuric acid or ammonium acetate provided the new bioactive naphthyridine alkaloids lophocladine A and B, respectively.

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