Corynoxidine

Names

[ Name ]:
Corynoxidine

[Synonym ]:
(7S,13aS)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline 7-oxide
Corynoxidin
corynoxidine

Biological Activity

[Description]:

(-)-Corynoxidine is an acetylcholinesterase inhibitor with an IC50 value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa[1].(-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees[2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Neuronal Signaling >> AChE

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 89.0 μM (acetylcholinesterase)[1]

[References]

[1]. Kim DK, et al. Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa. Arch Pharm Res. 2004 Nov;27(11):1127-31.

[2]. Yang DL, et al. A new antibacterial denitroaristolochic acid from the tubers of Stephania succifera. J Asian Nat Prod Res. 2013;15(3):315-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₅NO₅

[ Molecular Weight ]:
371.42700

[ Exact Mass ]:
371.17300

[ PSA ]:
66.35000

[ LogP ]:
3.34790