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N-acetylputrescine

Names

[ CAS No. ]:
5699-41-2

[ Name ]:
N-acetylputrescine

[Synonym ]:
N-acetylputrescinehydrochloride
1-acetylamino-4-aminobutane
Acetylputrescine
N1-acetylputrescine
N-acetyl-1,4-butyl-diamine
4-acetylaminobutylamine
monoacetylputrescine
N-acetylputrescine
Putrescine,N-acetyl

Biological Activity

[Description]:

N-Acetylputrescine (NAP) is an endogenous metabolite widely present in animals and plants. N-Acetylputrescine can be used as a biomarker for lung squamous cell carcinoma (SCCL) and Parkinson's disease (PD) for disease diagnosis[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Neurological Disease

[In Vitro]

存在 [14C] 腐胺的情况下，N-Acetylputrescine 在人淋巴细胞中形成[4]。

[References]

[1]. Liu R, et al. Plasma N-acetylputrescine, cadaverine and 1,3-diaminopropane: potential biomarkers of lung cancer used to evaluate the efficacy of anticancer drugs. Oncotarget. 2017 Jul 17;8(51):88575-88585.  

[2]. Pfanzagl B, et al. N-acetylputrescine as a characteristic constituent of cyanelle peptidoglycan in glaucocystophyte algae. J Bacteriol. 1996 Dec;178(23):6994-7.  

[3]. Peng K W, et al. Identification and Validation of N-Acetylputrescine in Combination With Non-Canonical Clinical Features As a Parkinson’s Disease Biomarker Panel[J]. bioRxiv, 2021: 2021.07. 23.453542.

[4]. Menashe M, et al. Formulation of N-acetylputrescine and N1-acetylspermidine in cultured human lymphocytes. Biochem J. 1980 Apr 15;188(1):263-7.  

Chemical & Physical Properties

[ Density]:
0.948g/cm3

[ Boiling Point ]:
301ºC at 760mmHg

[ Molecular Formula ]:
C6H14N2O

[ Molecular Weight ]:
130.18800

[ Flash Point ]:
135.8ºC

[ Exact Mass ]:
130.11100

[ PSA ]:
58.61000

[ LogP ]:
1.40200

[ Index of Refraction ]:
1.48

MSDS

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Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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