Nε,Nε,Nε-Trimethyllysine chloride

Names

[ Name ]:
Nε,Nε,Nε-Trimethyllysine chloride

[Synonym ]:
[(5S)-5-amino-5-carboxypentyl]-trimethylazanium,chloride

Biological Activity

[Description]:

Nε,Nε,Nε-Trimethyllysine chloride serves as a precursor for gut flora-dependent formation of N,N,N-trimethyl-5-aminovaleric acid (TMAVA)[1].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

TMAVA as a novel gut flora metabolite generated from Nε,Nε,Nε-Trimethyllysine chloride[1].

[References]

[1]. Zhao M, et al. TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice. Gastroenterology. 2020;158(8):2266-2281.e27.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₂₁ClN₂O₂

[ Molecular Weight ]:
224.72800

[ Exact Mass ]:
224.12900

[ PSA ]:
66.15000

[ LogP ]:
0.44240

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Inhibition of histone binding by supramolecular hosts.

Biochem. J. 459(3) , 505-12, (2014)

The tandem PHD (plant homeodomain) fingers of the CHD4 (chromodomain helicase DNA-binding protein 4) ATPase are epigenetic readers that bind either unmodified histone H3 tails or H3K9me3 (histone H3 t...

A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1A.

Biochem. Biophys. Res. Commun. 455(3-4) , 382-9, (2014)

The elongation factors of Saccharomyces cerevisiae are extensively methylated, containing a total of ten methyllysine residues. Elongation factor methyltransferases (Efm1, Efm2, Efm3, and Efm4) cataly...

Tuning HP1α chromodomain selectivity for di- and trimethyllysine.

ChemBioChem. 12(18) , 2786-90, (2011)

Histone lysine methylation is a critical marker for controlling gene expression. The position and extent of methylation (mono-, di-, or tri-) controls the binding of effector proteins that determine w...

Related Compounds

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