JNJ 10181457 dihydrochloride

Names

[ Name ]:
JNJ 10181457 dihydrochloride

[Description]:

JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[In Vivo]

JNJ 10181457 (1 mg/kg，i.v.) 在雄性 Wistar 大鼠中，相比于生理盐水对照组，可以阻断组胺 (50 μg/kg) 或甲硫美哌 (50 μg/kg) 产生的迷走神经诱发的心动过缓反应的抑制作用[1]。

[References]

[ Molecular Formula ]:
C₂₀H₂₈N₂O

[ Molecular Weight ]:
312.45

[ Exact Mass ]:
384.17400

[ PSA ]:
15.71000

[ LogP ]:
4.22610