JNJ 17203212
Names
Biological Activity
[Description]:
JNJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1.IC50 value: 65 nM (human TRPV1), 102 nM (rat TRPV1)Target: TRPVin vivo: JNJ-17203212 reduces sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. Throughout this study, colonic sensitivity was assessed via quantification of VMR to CRD in rats following a single, oral administration of JNJ-17203212 (3, 10 or 30 mg/kg) or vehicle. [1] Oral pretreatment with JNJ-17203212 is a novel and selective TRPV1 antagonist, with partially prevents core hypothermia evoked by sc capsaicin. Oral pretreatment with JNJ-17203212 is a novel and selective TRPV1 antagonist, with partially prevents capsaicin-evoked hypothermia in a dose-response manner. [2]
[Related Catalog]:
[References]
[Related Small Molecules]
capsaicin
|
Capsazepine
|
EIPA
|
Diphenyleneiodonium chloride
|
HC-030031
|
SKF-96365
|
HC 067047
|
AMG 9810
|
GSK-1016790A
|
SAR7334
|
PF-4840154
|
RN-1734
|
AMG-517
|
SB-366791
|
IcilinAG-3-5
Chemical & Physical Properties
[ Molecular Formula ]:
C17H15F6N5O
[ Molecular Weight ]:
419.32400
[ Exact Mass ]:
419.11800
[ PSA ]:
61.36000
[ LogP ]:
3.94420
[ Storage condition ]:
2-8℃
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H319
[ Precautionary Statements ]:
P301 + P310-P305 + P351 + P338
[ RIDADR ]:
UN 2811 6.1 / PGIII