JNJ-37822681 dihydrochloride

Names

[ CAS No. ]:
2108806-02-4

[ Name ]:
JNJ-37822681 dihydrochloride

Biological Activity

[Description]:

JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[Target]

Ki: 158 nM (dopamine D(2))[1]


[References]

[1]. Langlois X, et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J Pharmacol Exp Ther. 2012 Jul;342(1):91-105.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H19Cl2F5N4

[ Molecular Weight ]:
445.26

Related Compounds