C24:1-Ceramide

Names

[ Name ]:
C24:1-Ceramide

[Synonym ]:
15-Tetracosenamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-, (15Z)-
(Z)-N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]tetracos-15-enamide
N-nervonoyl-D-erythro-sphingosine
15-Tetracosenamide, N-[(3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-, (15E)-
(15Z)-N-[(2S,3R,4E)-1,3-Dihydroxy-4-octadecen-2-yl]-15-tetracosenamide
(15E)-N-[(4E)-1,3-Dihydroxy-4-octadecen-2-yl]-15-tetracosenamide
N-(15Z)-tetracosenoylsphingosine
N-(15Z-tetracosenoyl)-sphing-4-enine

Biological Activity

[Description]:

C24:1-Ceramide is one of the most abundant naturally occurring ceramide. Ceramides regulates many diverse biological activities, such as cell apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> Stem Cell/Wnt >> GSK-3

Research Areas >> Others

Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[In Vitro]

C24:1-Ceramide 可结合磷酸化-Tyr-216-GSK3 (pYGSK3)[4]。 C24:1-Ceramide (1 μM, 48 h) 诱导室管膜细胞纤毛伸长[4]。

[References]

[1]. Gudz, T.I., et al. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. The Journal of Biological Chemisty 272(39), 24154-24158 (1997).

[2]. ugé, N., et al. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. The Journal of Biological Chemisty 271(32), 19251-19255 (1996).

[3]. Gu, Q., et al. Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry. Anal. Biochem. 244(2), 347-356 (1997).

[4]. Kong JN, et al. Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3. Mol Biol Cell. 2015 Dec 1;26(24):4451-65.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
749.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₂H₈₁NO₃

[ Molecular Weight ]:
648.097

[ Flash Point ]:
407.1±32.9 °C

[ Exact Mass ]:
647.621643

[ PSA ]:
69.56000

[ LogP ]:
17.07

[ Vapour Pressure ]:
0.0±5.7 mmHg at 25°C

[ Index of Refraction ]:
1.484

Safety Information

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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