54164-50-0

54164-50-0 structure

Name: C24:1-Ceramide
Chemical Name: N-Nervonoyl-D-sphingosine
CAS Number: 54164-50-0
Molecular Formula: C₄₂H₈₁NO₃
Molecular Weight: 648.097
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-10-24 07:50:48
Modify Date: 2024-01-05 08:46:46
C24:1-Ceramide is one of the most abundant naturally occurring ceramide. Ceramides regulates many diverse biological activities, such as cell apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain[1][2][3].

Name	N-Nervonoyl-D-sphingosine
Synonyms	15-Tetracosenamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-, (15Z)- (Z)-N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]tetracos-15-enamide N-nervonoyl-D-erythro-sphingosine 15-Tetracosenamide, N-[(3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-, (15E)- (15Z)-N-[(2S,3R,4E)-1,3-Dihydroxy-4-octadecen-2-yl]-15-tetracosenamide (15E)-N-[(4E)-1,3-Dihydroxy-4-octadecen-2-yl]-15-tetracosenamide N-(15Z)-tetracosenoylsphingosine N-(15Z-tetracosenoyl)-sphing-4-enine

Description	C24:1-Ceramide is one of the most abundant naturally occurring ceramide. Ceramides regulates many diverse biological activities, such as cell apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Others Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
In Vitro	C24:1-Ceramide 可结合磷酸化-Tyr-216-GSK3 (pYGSK3)[4]。 C24:1-Ceramide (1 μM, 48 h) 诱导室管膜细胞纤毛伸长[4]。
References	[1]. Gudz, T.I., et al. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. The Journal of Biological Chemisty 272(39), 24154-24158 (1997). [2]. ugé, N., et al. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. The Journal of Biological Chemisty 271(32), 19251-19255 (1996). [3]. Gu, Q., et al. Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry. Anal. Biochem. 244(2), 347-356 (1997). [4]. Kong JN, et al. Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3. Mol Biol Cell. 2015 Dec 1;26(24):4451-65.

Density	0.9±0.1 g/cm3
Boiling Point	749.6±60.0 °C at 760 mmHg
Molecular Formula	C₄₂H₈₁NO₃
Molecular Weight	648.097
Flash Point	407.1±32.9 °C
Exact Mass	647.621643
PSA	69.56000
LogP	17.07
Vapour Pressure	0.0±5.7 mmHg at 25°C
Index of Refraction	1.484

HS Code	2922199090

123-78-4

191354-88-8

~91%

54164-50-0

Literature: Goldstein, Alex S.; Lukyanov, Anatoly N.; Carlson, Paul A.; Paul Yager; Gelb, Michael H. Chemistry and Physics of Lipids, 1997 , vol. 88, # 1 p. 21 - 36

506-37-6

54164-50-0

Literature: Chemistry and Physics of Lipids, , vol. 88, # 1 p. 21 - 36

Precursor 3
123-78-4 191354-88-8 506-37-6
DownStream 0

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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