2-Bromoethanol

Names

[ CAS No. ]:
540-51-2

[ Name ]:
2-Bromoethanol

[Synonym ]:
MFCD00002827
EINECS 208-748-1
1-Bromo-2-ethanol
Ethanol,2-bromo
2-Bromo-1-ethanol
Ethanol, 2-bromo-
2-bromoethan-1-ol
2-bromoethyl alcohol
Bromoethanol
Glycol bromohydrin
2-Bromoethanol
2-hydroxyethyl bromide
b-Bromoethyl Alcohol
Ethylene Bromohydrin
1-bromo-2-hydroxyethane

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
136.2±13.0 °C at 760 mmHg

[ Melting Point ]:
-80 °C

[ Molecular Formula ]:
C₂H₅BrO

[ Molecular Weight ]:
124.965

[ Flash Point ]:
57.1±9.5 °C

[ Exact Mass ]:
123.952370

[ PSA ]:
20.23000

[ LogP ]:
0.23

[ Vapour density ]:
4.3 (vs air)

[ Vapour Pressure ]:
3.2±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.482

[ Stability ]:
Stable, but probably light sensitive. Hygroscopic. Incompatible with strong oxidizing agents. Flammable. Forms an azeotrope with water.

[ Water Solubility ]:
1-5 g/100 mL at 19 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ8225000

CHEMICAL NAME :: Ethanol, 2-bromo-

CAS REGISTRY NUMBER :: 540-51-2

BEILSTEIN REFERENCE NO. :: 0878140

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C2-H5-Br-O

MOLECULAR WEIGHT :: 124.98

WISWESSER LINE NOTATION :: Q2E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 43 gm/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Klebsiella pneumoniae

DOSE/DURATION :: 15 mmol/L

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 25,85,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4428 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H314

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R10;R26/27/28;R36/37/38;R40

[ Safety Phrases ]:
S26-S36/37/39-S45-S28A-S16

[ RIDADR ]:
UN 2922 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
KJ8225000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2905590090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2905590090

[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Halogenated derivatives QSAR model using spectral moments to predict haloacetic acids (HAA) mutagenicity.

Bioorg. Med. Chem. 16 , 5720-32, (2008)

The risk of the presence of haloacetic acids in drinking water as chlorination by-products and the shortage of experimental mutagenicity data for most of them requires a research work. This paper desc...

Preparation and mechanism insight of nuclear envelope-like polymer vesicles for facile loading of biomacromolecules and enhanced biocatalytic activity.

ACS Nano 8(7) , 6644-54, (2014)

The facile loading of sensitive and fragile biomacromolecules, such as glucose oxidase, hemoglobin, and ribonucleic acid (RNA), via synthetic vehicles directly in pure aqueous media is an important te...

Determination of three estrogens and bisphenol A by functional ionic liquid dispersive liquid-phase microextraction coupled with ultra-high performance liquid chromatography and ultraviolet detection.

J. Sep. Sci. 38 , 2158-66, (2015)

A hydroxyl-functionalized ionic liquid, 1-hydroxyethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide, was employed in an improved dispersive liquid-phase microextraction method coupled with u...