Propynol Ethoxylate

Names

[ Name ]:
Propynol Ethoxylate

[Synonym ]:
MFCD06411441
EINECS 223-601-1
2-(2-Propyn-1-yloxy)ethanol
Propynol ethoxylate
Ethanol, 2-(2-propyn-1-yloxy)-
2-(Prop-2-yn-1-yloxy)ethanol
PME

Biological Activity

[Description]:

Propynol Ethoxylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
168.7±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₈O₂

[ Molecular Weight ]:
100.116

[ Flash Point ]:
68.9±14.6 °C

[ Exact Mass ]:
100.052429

[ PSA ]:
29.46000

[ LogP ]:
-0.25

[ Vapour Pressure ]:
0.5±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.446

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36

[ Safety Phrases ]:
26

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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