ZMVR DZ

Names

[ Name ]:
ZMVR DZ

[Synonym ]:
EINECS 226-324-4
p-Aminobenzoyl Hydrazide
4-aminobenzhydrazide
Aminostimil
(4-Aminobenzoyl)hydrazide
Amben hydrazide
p-Aminobenzhydrazide
4-Aminobenzoylhydrazide
4-aminobenzenecarbonylhydrazine
4-Aminobenzoic acid hydrazide
4-Aminobenzohydrazide
ZMVR DZ
Benzoic acid, 4-amino-, hydrazide
4-Aminobenzoylhydrazine
4-Aminobenzoic hydrazide
MFCD00007606
p-Aminobenzoic acid hydrazide

Biological Activity

[Description]:

4-Aminobenzohydrazide is an irreversible MPO myeloperoxidase inhibitor with an IC50 of 0.3 µM[1]. It is used for the research of subacute stroke[2].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Kettle AJ, et al. Inhibition of myeloperoxidase by benzoic acid hydrazides. Biochem J. 1995 Jun 1;308 ( Pt 2)(Pt 2):559-63.

[2]. Forghani R, et al. Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke. J Cereb Blood Flow Metab. 2015 Mar;35(3):485-93.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Melting Point ]:
225-227 °C(lit.)

[ Molecular Formula ]:
C₇H₉N₃O

[ Molecular Weight ]:
151.17

[ Exact Mass ]:
151.074554

[ PSA ]:
81.14000

[ LogP ]:
-0.75

[ Index of Refraction ]:
1.641

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG2580000

CHEMICAL NAME :: Benzoic acid, p-amino-, hydrazide

CAS REGISTRY NUMBER :: 5351-17-7

BEILSTEIN REFERENCE NO. :: 0639053

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H9-N3-O

MOLECULAR WEIGHT :: 151.19

WISWESSER LINE NOTATION :: ZNUYQR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01358

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG2580000

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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