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Lexithromycin

Names

[ CAS No. ]:
53066-26-5

[ Name ]:
Lexithromycin

[Synonym ]:
(E)-9-chloro-4-methyl-8-(tetrahydro-2H-pyran-2-yloxy)-4-nonenoic acid
4-Nonenoic acid,9-chloro-4-methyl-8-[(tetrahydro-2H-pyran-2-yl)oxy]

Biological Activity

[Description]:

Lexithromycin is an erythromycin A derivative, with antibacterial activity.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial
Research Areas >> Infection

[Target]

Bacterial[1]


[In Vitro]

Lexithromycin is an erythromycin A derivative, with antibacterial activity. Lexithromycin shows minimal inhibitory concentration (MIC) of 0.06 μg/mL against S. pyogenes CN10A and Streptococcus sp. 64/848C, 0.25 μg/mL against Staphylococcus aureus Oxford, 0.5 μg/mL against S. aureus Russell and S. aureus T2, 4 μg/mL against S. pyogenes CN10A and Haemophilus influenzae Wy 21[1].

[References]

[1]. Hunt E, et al. Erythromycin A 11,12-methylene acetal. J Antibiot (Tokyo). 1988 Nov;41(11):1644-8.


[Related Small Molecules]

Puromycin 2HCl | Geneticin | Tunicamycin | Hygromycin B | Salinomycin | Avibactam sodium | Neomycin sulfate | Vaborbactam | Methicillin SodiuM | Rifampicin | Metronidazole | Carbenicillin disodium | Ceftazidime | Eravacycline dihydrochloride | cefotaxime sodium

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
824.6ºC at 760mmHg

[ Molecular Formula ]:
C38H70N2O13

[ Molecular Weight ]:
762.96800

[ Flash Point ]:
452.5ºC

[ Exact Mass ]:
762.48800

[ PSA ]:
198.43000

[ LogP ]:
2.21890

[ Index of Refraction ]:
1.543

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Related Compounds

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