bPiDDB

Names

[ Name ]:
bPiDDB

Biological Activity

[Description]:

bPiDDB is a potent nAChR antagonist. bPiDDB potently (IC50=2 nM) inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[In Vivo]

bPiDDB (外周给药) 可抑制伏隔核中尼古丁诱发的多巴胺 (DA) 释放，降低大鼠尼古丁的成瘾性[1]。 bPiDDB 在外周给药后具有脑生物可利用性，并由血脑屏障胆碱转运体主动运输到中央室[1]。

[References]

[1]. Smith AM, et al. Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release. Biochem Pharmacol. 2010 Aug 1;80(3):402-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₈Br₂N₂

[ Molecular Weight ]:
514.38000

[ Exact Mass ]:
512.14000

[ PSA ]:
7.76000

Related Compounds

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