Hematoxylin

Names

[ CAS No. ]:
517-28-2

[ Name ]:
Hematoxylin

[Synonym ]:
Hematoxylin Hydrate
MFCD00005394
HAEMATOXYLIN(RG)
bematoxylin
Hematoxylin
Natural Black 1
Natural Black 1 Hydrate
Haematoxylin
Homaeoxylin
hydroxybrazilin
EINECS 208-237-3
h(a)ematine

Biological Activity

[Description]:

Hematoxylin is a natural product.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

Natural Products >> Phenols

[References]

[1]. EF Kingston, et al. Vascular invasion is underrecognized in colorectal cancer using conventional hematoxylin and eosin staining. 《Diseases of the Colon & Rectum》, 2007, 50(11):1867-1872

[2]. JE Grilley-Olson, et al. Validation of interobserver agreement in lung cancer assessment: hematoxylin-eosin diagnostic reproducibility for non-small cell lung cancer: the 2004 World Health Organization classification and therapeutically relevant subsets.

[3]. HR Zare, et al. Simultaneous determination of ascorbic acid, adrenaline and uric acid at a hematoxylin multi-wall carbon nanotube modified glassy carbon electrode. Sensors & Actuators B Chemical, 2010, 143(2):666-672

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
579.9±50.0 °C at 760 mmHg

[ Melting Point ]:
200 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₆H₁₄O₆

[ Molecular Weight ]:
302.279

[ Flash Point ]:
304.5±30.1 °C

[ Exact Mass ]:
302.079041

[ PSA ]:
110.38000

[ LogP ]:
0.51

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.810

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stability Stable, but may discolour on exposure to light. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MH7875000

CHEMICAL NAME :: Hematoxylin

CAS REGISTRY NUMBER :: 517-28-2

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H14-O6

MOLECULAR WEIGHT :: 302.30

WISWESSER LINE NOTATION :: T C6 B566 LO&TT&J EQ FQ JQ NQ OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg/26W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease

REFERENCE :: GASTAB Gastroenterology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1943- Volume(issue)/page/year: 23,1,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80980 No. of Facilities: 667 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 3015 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80980 No. of Facilities: 1405 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 24188 (estimated) No. of Female Employees: 20340 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
MH7875000

[ HS Code ]:
3302101000

Customs

[ HS Code ]: 2906299090

[ Summary ]:
2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion, and metastasis.

Cancer Res. 75(6) , 1102-12, (2015)

The translation initiation factor eIF4E is an oncogene that is commonly overexpressed in primary breast cancers and metastases. In this article, we report that a pharmacologic inhibitor of eIF4E funct...

Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.

Hum. Gene Ther. 26(3) , 172-82, (2015)

Intrauterine growth restriction (IUGR) due to placental insufficiency is a leading cause of perinatal complications for which there is no effective prenatal therapy. We have previously demonstrated th...

Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.

Autophagy 10(7) , 1241-55, (2014)

Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazol...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.