Azido-PEG5-amine

Names

[ Name ]:
Azido-PEG5-amine

[Synonym ]:
17-azido-3,6,9,12,15-pentaoxaheptadecanamine
5-PEG amino azide
17-azido-3,6,9,12,15-pentaoxa-1-heptadecylamine
17-azide-3,6,9,12,15-pentaoxaheptadecan-1-amine
Azido-PEG5-Amine
17-AZIDO-3,6,9,12,15-PENTAOXAHEPTADECAN-1-AMINE
1-amino-17-azido-3,6,9,12,15-pentaoxaheptadecane

Biological Activity

[Description]:

Azido-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₂₆N₄O₅

[ Molecular Weight ]:
306.35900

[ Exact Mass ]:
306.19000

[ PSA ]:
121.92000

[ LogP ]:
0.49146

[ Storage condition ]:
2-8°C

Azido-PEG5-amine

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds