Azido-PEG6-alcohol

Names

[ Name ]:
Azido-PEG6-alcohol

[Synonym ]:
17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol
2-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethanol
3,6,9,12,15-pentaoxa-17-azidoheptadecan-1-ol
17-azido-3,6,9,12,15-pentaoxa-1-heptadecanol
23-azido-3,6,9,12,15,-heptaoxatricosan-1-ol
17-azido-3,6,9,12,15-pentaoxaheptadecanol

Biological Activity

[Description]:

Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-alcohol is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.

[2]. Loredana Vesci, et al. HDAC INHIBITORS-BASED ANTIBODY DRUG CONJUGATES (ADCs) AND USE IN THERAPY. WO2018178060A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₂₅N₃O₆

[ Molecular Weight ]:
307.34300

[ Exact Mass ]:
307.17400

[ PSA ]:
116.13000

[ Storage condition ]:
-20°C

Precursor & DownStream

Precursor

DownStream

Related Compounds

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