Azido-PEG5-alcohol

Names

[ Name ]:
Azido-PEG5-alcohol

[Synonym ]:
3,6,9,12-Tetraoxatetradecan-1-ol, 14-azido-
14-Azido-3,6,9,12-tetraoxatetradecan-1-ol
2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol

Biological Activity

[Description]:

Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc(II) phthalocyanine conjugates. ChemMedChem. 2015 Feb;10(2):312-20.

[2]. Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₂₁N₃O₅

[ Molecular Weight ]:
263.291

[ Flash Point ]:
100 °C

[ Exact Mass ]:
263.148132

[ PSA ]:
106.90000

[ LogP ]:
-1.59

[ Index of Refraction ]:
1.47

MSDS

Click to get detail MSDS

Related Compounds

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