Azido-PEG5-PFP ester

Names

[ Name ]:
Azido-PEG5-PFP ester

[Synonym ]:
MFCD26793782
3,6,9,12,15-Pentaoxaoctadecan-18-oic acid, 1-azido-, 2,3,4,5,6-pentafluorophenyl ester
Pentafluorophenyl 1-azido-3,6,9,12,15-pentaoxaoctadecan-18-oate

Biological Activity

[Description]:

Azido-PEG5-PFP ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₄F₅N₃O₇

[ Molecular Weight ]:
501.402

[ Exact Mass ]:
501.153442

[ LogP ]:
1.31

Related Compounds

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