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Entasobulin

Names

[ CAS No. ]:
501921-61-5

[ Name ]:
Entasobulin

[Synonym ]:
2-[1-(4-chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-(quinolin-6-yl)acetamide
1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-6-quinolinyl-
entasobulin
TB77GU6BFO
2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-(6-quinolinyl)acetamide

Biological Activity

[Description]:

Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Research Areas >> Cancer

[Target]

β-tubulin polymerization


[In Vitro]

Entasobulin is a indolizine-glyoxylamide based small molecule that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes.

[Related Small Molecules]

Nocodazole | Monomethyl auristatin E | VcMMAE | Mertansine | Eribulin mesylate | Epothilone D | Vinorelbine (ditartrate) | epothilone B | McMMAF | MMAF (Hydrochloride) | Ixabepilone | Taltobulin | Estramustine phosphate sodium | Ansamitocin P-3 | Combretastatin A4 disodium phosphate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C26H18ClN3O2

[ Molecular Weight ]:
439.893

[ Exact Mass ]:
439.108765

[ LogP ]:
5.36

[ Index of Refraction ]:
1.683

[ Storage condition ]:
2-8℃

Related Compounds

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