INO-1001

Names

[ Name ]:
INO-1001

[Synonym ]:
9-[N-(3-[morpholin-4-yl]propyl)-aminosulphonyl]-5,6-dihydro-5-oxo-11H-indeno[1,2-c]isoquinoline
inotec indeno[1,2c]isoquinoline
9H-Xanthene,9-[bis(4-methoxyphenyl)methylene]
9-[N-(3-[morpholino-4-yl]propyl)-aminosulphonyl]-5,6-dihydro-5-oxo-11H-indeno-[1,2-c]isoquinoline
9-<Bis-(4-methoxy-phenyl)-methylen>-xanthen

Biological Activity

[Description]:

INO-1001 is a potent and selective Poly (ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 0.05-1 μM. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death[1]. INO-1001 has anti-tumor effects[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP:0.05-1 μM (IC50)

[References]

[1]. Brock WA, et al. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18;205(2):155-60.

[2]. Mason KA, et al. INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin. Invest New Drugs. 2008 Feb;26(1):1-5. Epub 2007 Jul 13.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₅N₃O₄S

[ Molecular Weight ]:
439.52700

[ Exact Mass ]:
439.15700

[ PSA ]:
100.14000

[ LogP ]:
3.92180

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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