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NEO 376

Names

[ CAS No. ]:
496921-73-4

[ Name ]:
NEO 376

[Synonym ]:
4H-Indol-4-one, 1-[2-[4-(3-chlorophenyl)-1-piperazinyl]ethyl]-1,5,6,7-tetrahydro-
1-{2-[4-(3-Chlorophenyl)-1-piperazinyl]ethyl}-1,5,6,7-tetrahydro-4H-indol-4-one

Biological Activity

[Description]:

NEO 376 is a selective modulator of 5-HT1 receptor, GABA receptor and dopamine receptor, with anti-psychotic actively.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Research Areas >> Neurological Disease

[References]

[1]. David B. Fick, et al. Tetrahydroindolone and purine derivatives linked to arylpiperazines. US 6770638 B2


[Related Small Molecules]

(+)-Bicuculline | Harmine | CB-154 mesylate | Pimavanserin | SCH 23390 hydrochloride | Levodopa | Picrotoxin | Aminooxyacetic acid hemihydrochloride | Riluzole | Cabergoline | Serotonin hydrochloride | Sodium Ferulate | Thioridazine hydrochloride | Brexpiprazole | Domperidone

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
547.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H24ClN3O

[ Molecular Weight ]:
357.877

[ Flash Point ]:
285.1±30.1 °C

[ Exact Mass ]:
357.160797

[ LogP ]:
4.30

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
2-8℃

Related Compounds

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