4'-Methylchrysoeriol

Names

[ Name ]:
4'-Methylchrysoeriol

[Synonym ]:
Kaempferol 3,4'-dimethyl ether
5,7-dihydroxy-3',4'-dimethoxyflavone
3',4'-dimethoxy-5,7-dihydroxyflavone
3'4'-dimethoxyluteolin
Kampferol-3,4'-dimethyl ether
luteolin-3',4'-dimethyl ether

Biological Activity

[Description]:

4'-Methylchrysoeriol is a potent inhibitor of Cytochrome P450 enzymes, with an IC50 of 19 nM for human P450 1B1-dependent EROD.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Cancer

[Target]

IC50: 19 nM ( human P450 1B1-dependent EROD)[1].

[In Vitro]

4'-Methylchrysoeriol (34DM57DHF) is a potent inhibitor of P450 enzymes, particularly for P450 1B1, with an IC50 of 19 nM for human P450 1B1-dependent EROD[1].

[References]

[1]. Shimada T, et al. Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. Chem Res Toxicol. 2009 Jul;22(7):1325-33.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.402g/cm3

[ Boiling Point ]:
538.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₄O₆

[ Molecular Weight ]:
314.28900

[ Flash Point ]:
201.3ºC

[ Exact Mass ]:
314.07900

[ PSA ]:
89.13000

[ LogP ]:
2.88840

[ Index of Refraction ]:
1.645

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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