Isosinensetin

Names

[ Name ]:
Isosinensetin

[Synonym ]:
2-(3,4-Dimethoxyphenyl)-5,7,8-trimethoxy-4H-chromen-4-one
6-Demethoxynobiletin
UNII-63Z99S38LE
5,7,8,3',4'-pentamethoxyflavone
Isosinensetin
3',4',5,7,8-Pentamethoxyflavone
4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,7,8-trimethoxy-

Biological Activity

[Description]:

Isosinensetin, a polymethoxylated flavone extracted from pericarpium citri reticulatae viride, exhibits inhibition on P-glycoprotein (P-gp) in MDR1-MDCKII cells[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[Target]

P-glycoprotein[2]

[References]

[1]. Wang D, et al. Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques. J Pharm Biomed Anal. 2007 May 9;44(1):63-9.

[2]. Bai J, et al. Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships. Toxicol Appl Pharmacol. 2019 Apr 15;369:49-59.

Chemical & Physical Properties

[ Density]:
1.244±0.06 g/cm3 (20 ºC 760 Torr)

[ Boiling Point ]:
565.3±50.0 °C at 760 mmHg

[ Melting Point ]:
198-199 ºC

[ Molecular Formula ]:
C₂₀H₂₀O₇

[ Molecular Weight ]:
372.369

[ Flash Point ]:
248.4±30.2 °C

[ Exact Mass ]:
372.120911

[ PSA ]:
76.36000

[ LogP ]:
2.88

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.566

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932999099

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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