Tranylcypromine (2-PCPA) HCl

Names

[ CAS No. ]:
4548-34-9

[ Name ]:
Tranylcypromine (2-PCPA) HCl

[Synonym ]:
Tranylcypromine (2-PCPA) HCl
(1S,2R)-2-Phenylcyclopropan-1-amine hydrochloride
Tranylcypromine
(+)-TRANYLCYPROMINE HYDROCHLORIDE

Biological Activity

[Description]:

(1S,2R)-Tranylcypromine hydrochloride is a potent antidepressant agent. (1S,2R)-Tranylcypromine hydrochloride can inhibits MAO and LSD1[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Histone Demethylase
Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Neurological Disease

[References]

[1]. TetsuyaEzawa, et al. Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1S,2R)-tranylcypromine. Tetrahedron: Asymmetry. 15 December 2017;28(12):1690-1699.

[2]. Valente S, et al. Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies. ACS Med Chem Lett. 2014 Dec 8;6(2):173-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H12ClN

[ Molecular Weight ]:
169.65100

[ Exact Mass ]:
169.06600

[ PSA ]:
26.02000

[ LogP ]:
3.00350

[ Storage condition ]:
-20℃