2-amino-9-(β-D-ribofuranosyl)purine

Names

[ Name ]:
2-amino-9-(β-D-ribofuranosyl)purine

[Synonym ]:
9H-purine, 2-amino-9-β-d-ribofuranosyl-,
9-(β-D-Ribofuranosyl)-9H-purin-2-amine
9H-Purin-2-amine, 9-β-D-ribofuranosyl-
2-amino-9-(β-D-ribofuranosyl)purine
9H-Purine, 2-amino-9-β-D-ribofuranosyl-
2-(2-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Biological Activity

[Description]:

(2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (9-pentofuranosyl-9H-purin-2-amine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
711.8±70.0 °C at 760 mmHg

[ Melting Point ]:
105-115ºC

[ Molecular Formula ]:
C₁₀H₁₃N₅O₄

[ Molecular Weight ]:
267.24

[ Flash Point ]:
384.3±35.7 °C

[ Exact Mass ]:
267.096741

[ PSA ]:
139.54000

[ LogP ]:
-1.40

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.907

Safety Information

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%