BAY-4931

Names

[ CAS No. ]:
423150-91-8

[ Name ]:
BAY-4931

Biological Activity

[Description]:

BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

[Target]

PPAR-γ:0.17 nM (IC50, RT112-FABP4-NLucP cellular reporter assay)

mouse PPARγ:0.14 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay )

hPPARγ:0.40 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay )

[In Vitro]

BAY-4931 (0-10 μM; 7 days) inhibits UM-UC-9 proliferation with an IC50 of 3.4 nM[1]. BAY-4931 only inhibits CYP2C8 in CYP inhibition test[1]. Cell Proliferation Assay[1] Cell Line: UM-UC-9 cells Concentration: 0-10 μM Incubation Time: 7 days Result: Inhibited proliferation with an IC50 of 3.4 nM.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₆ClN₃O₄

[ Molecular Weight ]:
421.83

Related Compounds

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