423150-91-8
423150-91-8 structure
- Name: BAY-4931
- Chemical Name: BAY-4931
- CAS Number: 423150-91-8
- Molecular Formula: C22H16ClN3O4
- Molecular Weight: 421.83
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
- Create Date: 2022-12-06 12:54:34
- Modify Date: 2024-04-02 14:45:24
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BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM[1].
| Name | BAY-4931 |
|---|
| Description | BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
PPAR-γ:0.17 nM (IC50, RT112-FABP4-NLucP cellular reporter assay) mouse PPARγ:0.14 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay ) hPPARγ:0.40 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay ) |
| In Vitro | BAY-4931 (0-10 μM; 7 days) inhibits UM-UC-9 proliferation with an IC50 of 3.4 nM[1]. BAY-4931 only inhibits CYP2C8 in CYP inhibition test[1]. Cell Proliferation Assay[1] Cell Line: UM-UC-9 cells Concentration: 0-10 μM Incubation Time: 7 days Result: Inhibited proliferation with an IC50 of 3.4 nM. |
| Molecular Formula | C22H16ClN3O4 |
|---|---|
| Molecular Weight | 421.83 |