RUVBL1/2 ATPase-IN-1

Names

[ Name ]:
RUVBL1/2 ATPase-IN-1

Biological Activity

[Description]:

RUVBL1/2 ATPase-IN-1 (compound 18) is a potent and selective inhibitor of RUVBL1/2 ATPase with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1 and RUVBL2 are highly conserved AAA ATPases (ATPases Associated with various cellular Activities) and highly relevant to the progression of cancer. RUVBL1/2 ATPase-IN-1 has the potential for the research of cancer diseases[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Zhang G, et al. Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem. 2022;62:116726.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₈F₃N₅O

[ Molecular Weight ]:
507.55

Related Compounds

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