PARP-1/2-IN-1

Names

[ CAS No. ]:
1903744-45-5

[ Name ]:
PARP-1/2-IN-1

Biological Activity

[Description]:

PARP-1/2-IN-1 is a potent PARP-1/2 inhibitor with IC50 of 0.51 nM and 23.11 nM, respectively.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PARP

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP:0.51 nM (IC50)

[References]

[1]. Zhou J, et al. Discovery of Quinazoline-2,4(1H,3H)-dione Derivatives Containing 3-Substituted Piperizines as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J Med Chem. 2021 Nov 8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₇FN₄O₃

[ Molecular Weight ]:
438.49

Related Compounds

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