Mycobactin-IN-2

Names

[ Name ]:
Mycobactin-IN-2

Biological Activity

[Description]:

Mycobactin-IN-2 (compound 49) is a mycobactin biosynthesis inhibitor against mycobacteria. Mycobactin-IN-2 binds to salicyl-AMP ligase (MbtA), a key enzyme in the mycobactin biosynthetic pathway[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Mycobactin[1]

[In Vitro]

Mycobactin-IN-2 exhibits notable activity against M. tuberculosis in iron-impoverished media with MIC90 8 μg/mL[1].

[References]

[1]. Shyam M, et, al. Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition. J Med Chem. 2022 Jan 13;65(1):234-256.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₃BrN₂O

[ Molecular Weight ]:
317.18

Related Compounds

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