Isaxonine

Names

[ Name ]:
Isaxonine

[Synonym ]:
isopropylaminopyrimidine
2-Pyrimidinamine,N-(1-methylethyl)
Isaxonine
Isaxonina
2-(N-isopropylamino)pyrimidine
Isaxonina [INN-Spanish]
Isaxoninum
Isaxoninum [INN-Latin]
isopropyl(pyrimidin-2-yl)amine
2-(ISOPROPYLAMINO)PYRIMIDINE

Biological Activity

[Description]:

Isaxonine acts as a modifier of the surface pH of the bilayer[1]. Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery[2]. Isaxonine is a neurotrophic agent[3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Isaxonine has a favourable effect on nerve regeneration. After 8 weeks small type grouping is seen in rats receiving solvent only and large type grouping in rats treated with intraperitoneal Isaxonine. After 10 weeks a checkerboard pattern of the fibre types is observed in the muscles of animals receiving solvent only but fibre type grouping was present in those treated with Isaxonine. Isaxonine prevents synaptic remodelling by suppression of the redundant nerve endings from additional axons, which have regenerated more slowly, in making contact with motor endplates[4]. Isaxonine phosphate induces acute hepatitis which in most cases is reversible after withdrawal of the compound[5].

[References]

[1]. De Bleecker J, et al. Influence of isaxonine on the target phenomenon, muscle fibre size and neuromuscular junction in the tenotomized and denervated gastrocnemius muscle of the rat. Acta Neuropathol. 1986;69(3-4):337-340.

[2]. J De Bleecker, et al. Influence of Isaxonine on the target phenomenon, muscle fibre size and neuromuscular junction in the tenotomized and denervated gastrocnemius muscle of the rat. Acta Neuropathol. 1986;69(3-4):337-40.

[3]. C M Becker, et al. Nerve and muscle regeneration after axonal division in rats treated with Isaxonine phosphate (isopropylamino-2-pyrimidine phosphate). Eur Surg Res. 1986;18(6):383-9.

[4]. J De Reuck, et al. Influence of Isaxonine on reinnervation of the rat gastrocnemius muscle. Acta Neuropathol. 1987;72(4):406-8.

[5]. A Davy, et al. [Hepatotoxicity of Isaxonine phosphate: 4 cases of severe subacute hepatitis]. Gastroenterol Clin Biol. 1984 Oct;8(10):715-9.

Chemical & Physical Properties

[ Density]:
1.065 g/cm3

[ Boiling Point ]:
229.3ºC at 760mmHg

[ Melting Point ]:
27-28ºC

[ Molecular Formula ]:
C₇H₁₁N₃

[ Molecular Weight ]:
137.18200

[ Flash Point ]:
92.5ºC

[ Exact Mass ]:
137.09500

[ PSA ]:
37.81000

[ LogP ]:
1.36990

[ Index of Refraction ]:
1.554

Safety Information

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%