RX 67668
Names
[ CAS No. ]:
40709-76-0
[ Name ]:
RX 67668
Biological Activity
[Description]:
RX 67668 is a potent cholinesterase inhibitor with an IC50 of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue[1][2].
[Related Catalog]:
[Target]
IC50: 5 μM (acetylcholinesterase) and 5 μM (butyrylcholinesterase)[1]
[In Vivo]
RX 67668 (1-4 mg/kg; i.p.) reduces by half the dose of methacholine necessary to produce red tears, whilst RX 67668 (7-2 mg/kg s.c.) is necessary to reduce the pupil diameter of the mouse to 50% of the control value[1]. Rat anterior tibialis preparation of the cat tibialis preparation demonstrates that RX 67668 (0.3-1.0 mg/kg; i.v.) is effective in reversing tubocurarine-induced muscle blockade[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C16H24ClN
[ Molecular Weight ]:
265.82100
[ Exact Mass ]:
265.16000
[ PSA ]:
3.24000
[ LogP ]:
4.54850