5'-O-Dimethoxytrityl-deoxythymidine

Names

[ Name ]:
5'-O-Dimethoxytrityl-deoxythymidine

[Synonym ]:
Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-
5'-O-dimethyltritylthymidine
5'-O-(Bis(4-methoxyphenyl)phenylmethyl)thymidine
EINECS 255-003-1
2,4(1H,3H)-pyrimidinedione, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-glycero-pentofuranosyl]-5-methyl-
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-[(2R,5S)-tetrahydro-5-[1-methoxy-1-(methyldioxy)-2,2,2-triphenylethyl]-2-furanyl]-
1-{5-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-β-D-glycero-pentofuranosyl}-5-methylpyrimidine-2,4(1H,3H)-dione
MFCD00010113
5′-O-(4,4′-Dimethoxytrityl)thymidine
5'-O-Dimethoxytrityl-deoxythymidine
1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
DMTr-dThd
5‘-O-Dimethoxytrityl-deoxythymidine
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]thymidine
1-{(2R,5S)-5-[1-Methoxy-1-(methylperoxy)-2,2,2-triphenylethyl]tetrahydro-2-furanyl}-5-methyl-2,4(1H,3H)-pyrimidinedione

Biological Activity

[Description]:

5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Research Areas >> Others

[References]

[1]. Lars Holmberg. Method and means for oligonucleotide synthesis. WO1992009615A1.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Melting Point ]:
114-116 °C (subl.)(lit.)

[ Molecular Formula ]:
C₃₁H₃₂N₂O₇

[ Molecular Weight ]:
528.596

[ Exact Mass ]:
528.226013

[ PSA ]:
112.01000

[ LogP ]:
6.97

[ Index of Refraction ]:
1.596

[ Storage condition ]:
−20°C

[ Stability ]:
Store in Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29349990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29349990

Articles

Solid-phase synthesis of polynucleotides. II. Synthesis of polythymidylic acids by the block coupling phosphotriester method.

Nucleic Acids Res. 8(22) , 5473-89, (1980)

Synthesis of two oligothymidylic acids, tridecamer and nonadecamer, is described by a rapid and simple solid-phase method on two kinds of polyacrylamide supports derivatized from commercially availabl...

Synthesis of mixed oligodeoxyribonucleotides following the solid phase method.

Nucleic Acids Res. 10(10) , 3291-301, (1982)

A method for the synthesis of mixed dimers, trimers and oligonucleotides on a solid support using monomeric protected nucleoside phosphochloridites (1a-d) has been developed and the different nucleosi...

Synthesis of 14 C-radiolabeled oligonucleotides with a novel phosphoramidite reagent.

Bioorg. Med. Chem. Lett. 8(9) , 1123-6, (1998)

A novel solid-phase synthesis of 5'-radiolabeled oligonucleotides is described. The labeling reaction is carried out by the phosphoramidite method with the aid of [4,6-di-14C]-5'-dimethoxytritylthymid...